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Branched-Chain Ketoacid Dehydrogenase (BCKDH) Branched-chain ketoacid dehydrogenase catalyzes the irreversible oxidative decarboxylation of BCKAs (Figures 2, 5), producing the respective branched-chain acyl-CoA derivates (isovaleryl-CoA from KIC, 2-methylbutyryl-CoA from KMV and isobutyryl-CoA from KIV) along with CO 2 and NADH

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Mai, PO

Proposed Mechanistic Model of ALC in Depression and Stress-Related Modulation ALC may exert antidepressant effects through converging mechanisms including mitochondrial bioenergetic enhancement, epigenetic upregulation of mGlu2 expression, and reduction of neuroinflammation

[DOI] [PubMed] [Google Scholar] 19.Petropoulos, I