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ArfGAP1 is known to function as a GAP for the Golgi-localized small GTPase Arf1, that mediates the dissociation of the COPI coatomer complex from Golgi-derived vesicles, a prerequisite for vesicle fusion with target compartments such as the endoplasmic reticulum (ER) [3640]

clinical trials in humans have been limited

In addition to detecting peptides from several proteins previously associated with IC/BPS, we also identified peptides from several proteins that have not been previously implicated in this disorder

Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function

An allergic reaction usually involves more immediate and specific symptoms like a localized rash, itching, or swelling