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It preserves lean muscle mass during rapid weight loss, maintains metabolic rate, and improves the ratio of fat loss to total weight loss

Critics point to methodological challenges and alternative interpretations of in vivo data

In this work, we found that the restriction of the metabolism of cysteine ( cysB and cysE ) and inhibition of glutathione synthesis ( gshAB ) did not lead to the expected increase, but to a decrease in the sensitivity of the gmhA mutant to antibiotics, which is especially pronounced in the case of such a bactericidal antibiotic as nalidixic acid

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However, it remains unclear whether compound 968 plays a similar role in AML cells