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The Foundation of Safety: Why B12 Is Different To understand the safety of B12 injections, it helps to understand the vitamin itself

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Germline P granules are liquid droplets that localize by controlled dissolution/condensation

Analyzing a series of studies using differing amounts of B12 via injection, the IOM determined that 1.5 g of absorbed B12 per day was enough to normalize red blood cell parameters (hematocrit, red blood cell volume, and anemia) in the average patient with pernicious anemia

Individual factors such as metabolic rate, body weight, and age may theoretically influence how B12 is distributed and utilised, though evidence for their impact on injection intervals is limited