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10.56093/ijans.v91i5.115394 115 LavrentiadouS

Patients must be 18 years or older to receive injections or have the written consent of a parent

It has been implicated in non-specific polyclonal activation of B cells, an event that would prevent the development of effective immune responses against the parasite ( Regarding SAPA, it was described that the C-terminal fragment of trans-sialidase is capable of activating B cells in a T-cell independent manner that leads to polyclonal antibody secretion ( On the other hand, Tc24 was shown to elicit a nonspecific B cell response secreting mainly IgM both in vivo and in vitro

[DOI] [PMC free article] [PubMed] [Google Scholar] 148.Mukaihara T., Hatanaka T., Nakano M., Oda K., Ausubel Frederick M

Unlike larger proteins, their small size allows them to bind to cell receptors with high specificity making them ideal for targeted therapeutic use