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High performance liquid chromatographic determination of subpicomole amounts of amino acids by precolumn fluorescence derivatization with o-phthaldialdehyde
A computer modeling study suggested that lipoic acid might bind to the intracellular tyrosine kinase domain of the insulin receptor and stabilize the active form of the enzyme (43)

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Moreover, if the change to be analyzed does not involve a pH shift, the R readouts directly reflect the differences in redox state between the initial and final conditions
