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Relationship to the GH-IGF-1 Axis Because this fragment does not appear to stimulate IGF-1 production in laboratory models, it provides researchers with a tool to study the IGF-1-independent aspects of GH signalling in metabolic biology

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The sophisticated process of mitochondrial biogenesis requires coordination between mtDNA and nDNA, including mtDNA transcription and translation, translation of nDNA-encoded transcripts, membrane recruitment, protein import, and assembly of the OXPHOS complexes (Wu et al., 1999), and PPARG coactivator 1 beta (PGC1) along with PPARG related-coactivator 1 (PRC) were discovered subsequently (Lin et al., 2002)

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