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General procedure for site-selective modification of peptides To a solution of peptide (12 mM) in 50 mM PB, pH 7 was added 1.2 equiv of compound 1 and mixed at rt
Conversely, in chronic alcohol use, ethanol is an inducer of CYP2E1, leading to a potential increase in the formation of NAPQI should an overdose of acetaminophen occur

Neurology (1993) 43:81724

Duran et al

doi: 10.1038/s41556-024-01503-x 147 WangSWangWLiXZhaoXWangYZhangHet al