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IV administration is used in some clinical settings to support liver function in patients with specific conditions - though this is not a reason to self-prescribe

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The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females

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doi: 10.1097/CM9.0000000000001474 2 Sarmento-RibeiroABScorilasAGoncalvesACEfferthTTrougakosIP

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