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However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]

31 Functional correlations between cellular organelles play key roles in maintaining homeostasis between mitochondria, lysosomes, and sEV biogenesis-associated endosomes

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2017 doi: 10.1016/j.cellsig.2017.10.014

The standard cycle is 8 to 12 weeks on, followed by 4 to 8 weeks off