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Beginning in 1963, the Schoenenberger-Monnier research group investigated whether specific compounds circulating in the bloodstream might contribute to the initiation and maintenance of sleep
Disrupting the p53-FOXO4 interaction using FOXO4-DRI caused p53 to be excluded from nucleus and directed to mitochondria for induction of apoptosis, ultimately eliminating the senescent cells
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Excluding the high-risk study in sensitivity analyses did not materially change the pooled effect estimate, supporting the robustness of the findings
