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Cell 167 , 16361649.e13 (2016)

Animal Models of Parkinsons Disease
This, in turn, inhibits NLRP3 inflammasome activation through an ARRB2-dependent mechanism [40,41,42]

These challenges, along with potential strategies to overcome them, are summarized in Figure 2, which highlights the translational barriers of NRF2-targeted therapies and outlines proposed solutions such as patient-derived models, selective inhibitors, and biomarker development