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Proposed new phenotype of ASD Based on our findings that a large subset of children with ASD in our multi-site cohort have elevated concentrations of one or more MDMs, we propose a new ASD phenotype, ASD associated with Microbially-Derived Metabolites (ASD-MDM), which is defined by quantitative laboratory measurements of MDMs in urine samples in young children

( A ) K48-linked or K63-linked tetraubiquitin chains were reacted with AMSH* (K63-linkage-specific deubiquitinase) and OTUB1* (K48-linkage specific deubiquitinase)

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doi: 10.1021/acscentsci.7b00589

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