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Moreover, the long-term effects, safety profiles, drug interactions, and patient-specific application of ferroptosis inhibitors remain unknown, warrants further studies

Reduction in MTHFR activity due to functional vitamin B2 deficiency, causes 5,10-methylene-THF to be stuck or trapped within the folate cycle, and there is an increase in 5,10-methylene-THF and a reduction in 5MTHF (Nijoult etal, 2004)

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