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Furthermore, the proteasome activity is downregulated in the liver of animal models of obesity and T2DM, with the accumulation of ubiquitinated proteins [90]

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111 Another potential benefit of MMS is that LMM can be detected prior to reconstruction, allowing accurate sentinel lymph node biopsy (SNLB) prior to complex reconstructions that would otherwise compromise SNLB

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As in adults, the biggest challenge is identifying appropriate candidates for therapy

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