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Although it is well characterized that pathological -synuclein propagates in a prion-like fashion from the stomach and duodenum to the brain via the vagus (Van Den Berge et al., 2019), how the appendix facilitates the pathological spread is unanswered since the evidence shows increased levels of -synuclein with significant enrichment within the axonal varicosities of the mucosal plexus ( via DNA methylation of genes related to the production of autophagic protein and lysosomal degradation pathways (Figure 3A) (Lei et al., 2019)

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More than 700,000 patients with suicidal bipolar depression are currently in need of treatment in the U.S

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Surgical Procedures Several surgical techniques are used to treat nerve injury, depending on the type of injury and the length of time that has passed since the injury