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An animal model study showed that spironolactone alleviated liver damage and portal hypertension by reducing intrahepatic resistance[56]
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Studies suggest that this excessive activation of the androgen receptor in hair follicles leads to follicular miniaturisation through a progressively shorter anagen phase, resulting in hair that grows thinner and shorter hair follicles that may not penetrate the epidermis
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Another study in the Journal of the American Heart Association found that the risk of major cardiovascular events in people with elevated TMAO was 60% greater than for those with normal TMAO
