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moreover, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation

In addition, there are certain limitations to polyphenol usage in clinical settings mainly in term of their bioaccessibility and bioavailability concerns
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Proteasome inhibition and multiple myeloma: Current concepts and future directions

AGPS, alkylglycerone phosphate synthase
