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Woodburn, K

Local drift analysis showed negative average annual changes in mortality for younger age groups (1.847 to 0.327 for ages 32.562.5 years) and positive changes for older age groups (0.2911.161 for ages 72.597.5 years)

As we age, our natural collagen production begins to dropoften starting as early as our mid-20s

See supplemental Table 3 and accompanying text for full details on multivariate analysis techniques and results

Liver cirrhosis is the 14th most common cause of death, being responsible for over a million deaths per year worldwide.1,2 Survival significantly decreases when the disease progresses to a decompensated phase.1 In fact, survival of patients with decompensated cirrhosis is 2 to 4 years, which is worse than survival associated with many oncologic diseases.3 Ascites is the most frequent decompensation, and once it develops, about one half of the patients will be dead in 5 years.4 The development of renal failure associates with further increase in mortality, with more than 60% of the patients being dead in one year.5 Advanced cirrhosis is associated with a decrease in plasmatic albumin.6 Patients with cirrhosis have impaired hepatocellular function and reduced albumin synthesis, which can reach a 60-80% reduction in advanced cirrhosis.7 Protein levels further decrease due to the dilution effect from water and salt retention, and to the sequestration of circulating albumin in extracellular space and ascitic fluid.8, 9 Importantly, albumin is a major prognostic factor, being a significant predictor of death in over a hundred studies in patients with cirrhosis.6 Albumin is a component of the most important and widely used prognostic score in cirrhosis, the Child-Pugh-Turcotte score.10 Recently, a new concept of effective albumin concentration indicates that not only serum albumin decreases in liver cirrhosis, but the quality of albumin also changes