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Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis

Particularly phase I reactions catalyzed by cytochrome P 450 enzymes (CYP enzymes) have been widely studied in liver microsomes (25) and with recombinant individual CYP enzyme isotypes (26)
These limitations become particularly pronounced when integrating more than two omics datasets, often leading to outputs with limited biological relevance 18

Four days after injection, the animals were euthanized by CO 2 and macrophages were harvested by washing their peritoneal cavity with 7 mL ice-cold PBS supplemented with 1 mM EDTA