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In some cases, the intracellular Ca 2+ binds to calmodulin (CAM), which further binds to the Ca + /calmodulin-dependent protein kinase II (CAMKII) and phosphorylates the AMPA receptor on the synaptic membrane, resulting in increased Na + conductance

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Copper deficiency and lipid metabolism Insufficient copper levels may also contribute to atherosclerosis development by affecting lipid metabolism

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