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Major sensory organs, including pigmented eyes and auditory structures, were well-formed, alongside distinct brain regions, such as the optic tectum, and defined craniofacial features

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That has negative effects on mitochondrial respiration and mTOR signaling in ID- mutant cancers (Fu et al

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257274, doi:10.1016/B978-0-12-394316-3.00008-9, PMID 23177989

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These misfolded aggregates evade normal protein quality control mechanisms and progressively accumulate within neurons

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