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Therefore, there is an incremental cost of $790,567 in the first year of converting patients to oral vitamin B12
doi: 10.1073/pnas.88.7.2811
Furthermore, peripheral insulin resistance triggered by uremia, metabolic acidosis and low-grade inflammation is common in CKD (80), leading to intra-portal hyperinsulinemia, but does not necessarily increase hepatic sensitivity to GH because of the reduced hepatic expression of IGF-I and GHR mRNA (81)
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Multiple system atrophy
