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In the oral cavity, LL-37 (a cathelicidin), histatins (salivary peptides), and human beta-defensins (HBDs) are produced continuously but their expression is suppressed by chronic inflammation, poor nutrition, and aging, contributing to periodontal disease progression

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doi: 10.1007/s10096-014-2081-3 50 GaoRKongCEbertLLiHQuXLiuZet al

Key limitations include poorly characterized pharmacokinetics (rapid absorption but extensive metabolism and low systemic bioavailability for eugenol), variable extract standardization, heterogeneous assay methodologies, and limited in vivo and clinical data

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