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Intriguingly, 50% (2 patients) in the intervention arm achieved a mTICI 3 recanalization, while none in the control arm achieved the same (Table 4)

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Oncology (2016) 90(6):299306

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Regarding treatment strategies, it is suggested that the marked decrease in GPx1 expression may be the major mechanism of tumor sensitization to anthracyclines [93] and that GPx1 can partially inhibit doxorubicin-induced cell death-related signaling in breast cancer by interfering with the activation of the sphingomyelin-ceramide pathway [85]

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As you will see in the table below, a heterozygous MTHFR does not always mean folate and B12 supplementation are needed

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