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For example, a high lactate level activates GPR81 on immune cells, endothelial cells, and adipocytes, subsequently leading to angiogenesis, immune escape, and chemotherapy resistance [378]
However, LAC combined with clozapine was found to not significantly improve the treatment effect of schizophrenic patients who were tolerant to clozapine (73) (Studies are summarized in Table 4)
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It also helps support cardiovascular health by improving heart muscle function and reducing oxidative stress in heart cells
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