can glutamate make glutathione Synthase - an overview Impaired Glutathione Synthesis in Neurodegeneration

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DKD is characterized by intestinal barrier dysfunction (leaky gut) and metabolic endotoxemia, creating a vicious cycle that sustains systemic inflammation and kidney injury

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This leads to peripheral and hepatic insulin resistance and compensatory intra-portal hyperinsulinemia, which results in increased hepatic GH sensitivity that aggravates the condition further ( Table 1