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they share the common properties of increasing brain glutamate concentration and neurotransmission and of activating rCMRglc in frontal areas and subcortical aminergic nuclei (Toth et al., 1993

In addition, given the impact of central regulation of TH on orexigenic neuropeptides (78), variable regulation of the HPT axis with altered leptin levels also could be responsible for this metabolic abnormality (20)

For example, the muco-aqueous tear layer greatly reduces drug residence time [40]

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