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Although many studies provide evidence for the observed link between the usage of metformin and deficiency of vitamin B12, there remains uncertainty regarding whether metformin directly causes anemia and, if so, whether this is primarily driven by deficiency of vitamin B12 in individuals with type 2 diabetes mellitus (T2DM) undergoing metformin therapy [48,49]

Table 1 Main constituents of turmeric oil measured by GC considering different SFE treatments (T1, T2, T4, T6 see Supplementary Table S1 for experimental conditions), optimum treatment (TO) and conventional hydrodistillation (Hd)

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Serious reactions are rare, but they happen when safety protocols slip