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In the literature review, very few randomized controlled trials and meta-analyses were identified, and those identified were excluded from the scope of the present expert Consensus Statement on the basis of insufficient quality and a lack of pertinent information

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monitoring the content of the R-isomer in the intermediate L-3-cyano-2-hydroxy-N,N,N-trimethyl-propanaminium using derivation agent (+)-methyl-6-methoxy-2-naphthaleneaceyl chloride by HPLC and controlling the content of the isomer in the intermediate in the definite range

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