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There was no bulging of the umbilicus while standing either

Gradual Introduction: Start with lower concentrations (e.g., 0.05% to 1%) and less frequent application (e.g., every other day) to allow the skin to acclimate, especially for sensitive skin types

In contrast, Fabbri et al

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and 15 g L 1 glucose and 7.5 g L 1 citrate in KDDC medium