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Despite some LDL-C reductions (6%25% in three subjects), the results were largely disappointing, with minimal transduction efficiency and transient metabolic effects

(2000) reported an increased secretion of both A-40 and A-42 when neuroblastoma cells were exposed to 50 g/dL of inorganic Hg concomitant with ROS overproduction (Olivieri et al., 2000), and a study conducted in aggregating brain-cell cultures of fetal rat telencephalon showed that MeHg (non-cytotoxic concentrations/1050 days) produced increased APP levels accompanied by ROS production and glia activation (Monnet-Tschudi et al., 2006)