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Regardless the importance of GST activity for cellular vitality and health, the GST gene cluster is a hotspot for DNA sequence mutations that leads to the expression of active but functionally different GST variant proteins

Studies on rat colonocytes reported that the lower crypt cells are very much more sensitive towards hydrogen peroxide-induced damage than the differentiated cells located at the crypt surface (Pere, 2013)

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GSH functions as a neurotransmitter and neuromodulator as it contains binding sites for putative receptors, most likely glutamate receptors ( in vitro study on a human neuroblastoma SK-N-BE cell line and concluded that pterostilbene, a natural stilbene found in blueberries, may modulate the cell division cycle by producing advantageous alterations in DNA methylation and holds potential as a therapeutic agent for prolonging the start or further development of ND ( 2 S against oxidative stress by enhancing the synthesis of GSH (58)

Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study