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FIGURE 5 Discussion We found here that -Glu-Glu produced excitatory actions on cultured hippocampal neurons by activating partially NMDA receptors, although -Glu-Glu has good affinity for all ionotropic glutamate receptors ( Nevertheless, -Glu-Glu elicited excitatory actions at low concentration (10 M) which were dependent on the integrity of synaptic transmission as TTX (500 nM) blocked both -Glu-Gluelicited [Ca 2+ ]i increases and increase in spontaneous synaptic transmission

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The possibility that the folate drug combination will attach to the receptor is increased since the folate affinity for its receptor on cancer cells is 100x higher than when the affinity for monoclonal antibodies is compared

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