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Moreover, siRNA knockdown of p97/VCP in HEK293 cells significantly increased the amount of ATP7A T994I retained in the TGN, directly implicating the aberrant interaction between these two proteins in the mislocalization of ATP7A T994I at the plasma membrane (Yi et al., 2012)

It includes only a specific part of the FOXO4 sequence crucial for interacting with p53

These structural changes are underpinned by activation of the PGC-1/fibronectin type III domain-containing protein 5 (FNDC5)/BDNF axis, with prolonged endurance training boosting BDNF synthesis across multiple brain regions [29]