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Within the human body, these compounds can modulate various metabolic pathways, acting as direct antioxidants (Reference Zhang, Gan and Li150) and influencing the expression or activity of antioxidant enzymes (Reference Lee and Park151)

79 In addition to enhancing these enzymes, AIH can also be markedly mitigated by regulating the expression or activity of cytochrome P450 enzymes

In consequence, hypothalamus activation occurs (red arrow)

Yang, H., et al., Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1

Addressing these obstacles requires a systematic trajectory, including multi-omics dissection at single-cell resolution, rigorous causal validation in physiologically relevant models, and integration of multidimensional datasets through artificial intelligence to construct predictive models for patient stratification and combination therapy optimization
