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Proteins that are transported via the Tim23 mediated TIM contain an amphipathic helix at their N-termini that, that like TOM transport, is referred to as a presequence
H.PetrakisI

Such effects may present acutely or following prolonged exposure, with outcomes ranging from reversible dysfunction to permanent damage affecting localized brain regions or the CNS as a whole (164)

Bateman RJ, Smith J, Donohue MC, Delmar P, Abbas R, Salloway S, Wojtowicz J, Blennow K, Bittner T, Black SE, et al
