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Understanding appropriate management for these complications can also help in treatment

Knockout of PDCE2 by CRISPR and expression of FLAG-tagged PDCE2 in THP-1 cells demonstrated that LPS-induced glutathionylation is associated with wild type PDCE2 but not mutant protein lacking the lipoamide-linking lysine residues

Dosing is 600-1200mg per day for severe cases and 300-600mg per day for mild cases/maintenance

The peptide does not appear to affect levels of insulin or IGF1 in studies thus far

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