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Glutathione levels also are lower and oxidative stress is higher in conditions associated with mitochondrial dysfunction, including ageing, HIV infection, diabetes, neurodegenerative disorders, cardiovascular disorders, neurometabolic diseases, cancer, obesity and other conditions

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The dysregulation of the opioid system in fibromyalgia is closely associated with a variety of neurobiological dysfunctions, including imbalances in major neurotransmitter systems, especially serotonin and noradrenaline [158]