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10.1016/j.bcab.2019.101393 Biocatal
the intermittent inflammatory response to these crystals results in gout flares which are characterised by painful, red, hot, swollen joints

Contraindications include a personal or family history of medullary thyroid carcinoma and multiple endocrine neoplasia syndrome type 2, with caution advised in those with a history of pancreatitis

Xue S, Chen S, Ge Y, Guan T, Han Y

When levels are chronically low, the shift tends to be gradual rather than dramatic
