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For instance, Fer-1, similar to other hydrophobic drug candidates, is unsuitable for clinical development because of its limited capacity to traverse the blood-brain barrier (BBB) and its poor water solubility [216]
Therefore, targeting IGFs may help solve the problem of tumor drug resistance
doi: 10.1016/j.brainres.2017.03.014
JHC, how is that possible
doi: 10.3389/fgene.2018.00247 53 BiragynAFerrucciL
