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Hum Genet 69:88

The long-term effects of such therapy in this patient group are unknown and before embarking on such a strategy a careful discussion about the risks and benefits should be undertaken with the child/parents Prior to the identification of mutations within the IGF1R gene there were reports of patients with abnormalities of chromosome 15 including monosomy, ring chromosome and unbalanced translocations

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Defining its role will require human studies that move beyond the APAP paradigm to include other common and clinically challenging forms of drug-induced liver injury

Doctors might start with intravenous sodium bicarbonate, then switch to oral soda pop or things like Bicitra for keeping things steady (NORD)