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Similar strategies, such as expressing a CBD-dermasptin B-1 fusion peptide in tobacco hairy roots, have also demonstrated enhanced antimicrobial activity against phytopathogens, particularly Alternaria alternata , compared to the unmodified peptide (Shams et al., 2019)

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In a recent phase Ib clinical trial focusing on domatinostat (a dual inhibitor of LSD1/HDAC) in patients with advanced melanoma, the drug failed to enhance the efficacy of treatments targeting anti-PD-1 and cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) while unexpected severe skin toxicity was observed

In a NSCLC model, inhibition of Met with PHA-665752 resulted in downregulation of hexokinase 2 (HK2), which is important for the initiation of glycolysis (ref