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Zafardoust et al., 2023a

Localization of insulin-like growth factor-I mRNA in rat brain by in situ hybridization--relationship to IGF-I receptors

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doi: 10.1271/bbb.66.2449

Many therapeutic mAbs directed against IGF-1R have been developed, and encouraging preclinical activity has been observed with ganitumab [53], figitumumab [54], dalotuzumab [67], R-1507 [55], robatumumab [56], and istiratumab, a tetravalent bispecific mAb that inhibits both IGF-1R and ErbB3 [57], in a wide range of tumor models [1]