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A study 14 found that in APP/PS1 mutant mice, the decrease in ALDH2 activity could lead to a cascade of downstream events, including disruption of mitochondrial integrity, accumulation of mitochondrial DNA in the cytoplasm, downregulation of the cGAS-STING-TBK1 signaling pathway, and inhibition of autophagy and mitophagy, ultimately resulting in cardiac disorders

10.1016/j.biopha.2018.09.095 90

In the liver, a major site of GSH metabolism, this consists of: a) extensive catabolism of GSH within biliary spaces (Ballatori et al., 1986b, 1988, 1989), as well as within sinusoidal compartments of some species (Hinchman and Ballatori, 1990, 1994), b) direct hepatic reabsorption of some of the breakdown products (Ballatori et al., 1986a, 1988

The GABAergic Deficit Hypothesis of Major Depressive Disorder. Molecular Psychiatry, vol

C., Sunshine, M., Varma, S., Doroshow, J