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However, spermatogonia loss was higher than Sertoli and Leydig cell loss after busulfan exposure (39) and because the status of spermatic germ cells depends on Leydig and Sertoli cells function, apoptosis of these supporting cells can also endanger vitality of spermatic germ cells (46)

Indeed it consists of two transmembrane domains, a large extracellular domain, and two short intracellular domains that are required for CD36 function after substrate binding (Su and Abumrad, 2009)

Exceeding this amount may increase the risk of side effects

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Funding This work was supported by R01CA228339 to KEW