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[6] In vitro data referenced within the study indicated that AOD-9604 may promote differentiation of adipose-derived mesenchymal stem cells toward osteogenic lineages and may stimulate production of proteoglycans and type II collagen in isolated bovine chondrocyte cultures, both critical components of the extracellular matrix underpinning cartilage structural integrity

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Parlanti E, DErrico M, Degan P, Calcagnile A, Zijno A, van der Pluijm I, van der Horst GT, Biard DS and Dogliotti E (2012) The cross talk between pathways in the repair of 8-oxo-7,8-dihydroguanine in mouse and human cells

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