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Similarly, NOX4 has been shown to be overexpressed in various tumor types and implicated in cellular proliferation and survival [35]

Abbreviations ABC: ATP-binding cassette ADE: Andrographolide AFFL: Alcohol-precipitated fraction of fig fruit latex Aila: Ailanthone ALO: Aloperine Andro: Andrographis APS: Astragalus polysaccharide ATLIII: Atractylenolide III BCRP: Breast cancer resistance protein CAV-1: Caveolin-1 ceRNA: Competing endogenous RNA CHE: Chelerythrine COPD: Chronic obstructive pulmonary disease CQ: Chloroquine CSC: Cancer stem cell CTC: Circulating tumour cell CTR1: Copper transporter 1 CTSB: Cathepsin B Cu: Copper ion DA: Dioscin-6-O-acetate DAMP: Danger-associated molecular pattern DCR: Disease control rate DFS: Disease-free survival DHA: Dihydroartemisinin DNMT: DNA methyltransferase ECM: Extracellular matrix EGCG: ()epigallocatechin3gallate EGFR: Epidermal growth factor receptor EGFR-TKI: Epidermal growth factor receptor tyrosine kinase inhibitor EMMPRIN: Extracellular matrix metalloproteinase inducer EMT: Epithelial-mesenchymal transition ER: Endoplasmic reticulum ESI: Isodeoxyelephantopin EVO: Evodiamine FTH1: Ferritin heavy chain 1 GA: Glycyrrhizic acid GLI1: GLI family zinc finger 1 GLUT1: Glucose transporter 1 GNA: Gambogenic acid GP: Ginseng polysaccharide GPS: Gentiopicroside GPX4: Glutathione peroxidase 4 GSH: Glutathione HIF-1: Hypoxia-inducible factors-1 HK2: Hexokinase 2 HR: Hazard ratio HRE: Hypoxia-responsive element HSF1: Heat shock factor 1 IDO: Indoleamine-2,3-dioxygenase-1 IRE: Iron-responsive element IRP: Iron-regulatory protein ISO: Isoorientin JNK: c-Jun N-terminal protein kinase Keap1: Kelch-like ECH associated protein 1 KPS: Karnofsky Performance Status Kyn: Kynurenine LC3: Microtubule-associated protein 1 light chain 3 LDHA: Lactate dehydrogenase A LLC: Lewis lung cancer lico A: Licochalcone A lncRNA: Long non-coding RNA LRPPRC: Leucine-rich pentatricopeptide repeat-containing protein MDA: Malondialdehyde MDSC: Myeloid-derived suppressor cell MICU3: Mitochondrial calcium uptake protein 3 miR: MicroRNA MLKL: Mixed lineage kinase domain-like protein MMP: Matrix metalloproteinase mOS: Median overall survival mPFS: Median progression-free survival MRP: Multidrug resistance associated protein mtDNA: Mitochondrial DNA MTE: Marsdenia tenacissima extract NAC: N-acetylcysteine NCCN: National Comprehensive Cancer Network NEAT1: Nuclear enriched abundant transcript 1 NK: Natural killer Nrf2: Nuclear factor erythroid 2-related factor 2 NSCLC: Non-small-cell lung cancer ORR: Objective response rate OST: Osthole PD-1: Programmed cell death protein 1 PDK: Pyruvate dehydrogenase kinase P-gp: P-glycoprotein PKM: Pyruvate kinase M PL-OOH: Phospholipid hydroperoxide POL: Polygonatum odoratum lectin PPI: Polyphyllin I Pris: Pristimerin PRR: Pattern recognition receptor PTEN: Phosphatase and tensin homologue QOL: Quality of life RA: Rosmarinic acid RCT: Randomized controlled trial RECK: Reversion-inducing cysteine-rich protein with Kazal motifs RocA: Rocaglamide ROS: Reactive oxygen species RR: Relative ratio SA: Sappanone A SBE: Scutellaria barbata D.Don extract SCLC: Small-cell lung cancer SFA: Sophoridine A SHH: Sonic Hedgehog SMO: Smoothened SNH: Sodium new houttuyfonate SOX2: Sex determining region Y-box 2 Sp1: Specificity protein 1 STAT3: Signal transducer and activator of transcription 3 TAM: Tumour-associated macrophage TCM: Traditional Chinese medicine TCS: Trichosanthin TIMP: Tissue inhibitors of metalloproteinase TG: Tangeretin TGF-1: Transforming growth factor-beta1 TIIA: Tanshinone IIA Tim-AIII: Timosaponin AIII TPL: Triptolide TPT: topotecan TPT@CL-MOF: Topotecan-loaded crosslinked cyclodextrin metal-organic framework TRAIL: Tumour necrosis factorrelated apoptosisinducing ligand Treg: Regulatory T cell Trp: Tryptophan TSA: Tanshinol A TXNRD1 : Thioredoxin reductase 1 VEGF: Vascular endothelial growth factor WSG: Water-soluble polysaccharide from Geranium lucidum L

These oxidation products are a potential source for oxidative reactions in the plasma, but to a greater extent when the lower molecular weight Hb dimers are taken up into cells and tissues

Apoptosis is induced via two main routes involving either the mitochondria (the intrinsic pathway) or the activation of death receptors (the extrinsic pathway)