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National Library of Medicine: "B Vitamins" Mayo Clinic: "Biotin (Oral Route)" FDA: FDA 101: Dietary Supplements Mayo Clinic: "Anaphylaxis" Mayo Clinic: "Niacin" Mayo Clinic: "Allergies" Vitamin B12 - "Health Professional Fact Sheet" National Institutes of Health: "Vitamin B12 - Health Professional Fact Sheet" Journal of Allergy and Clinical Immunology: Vitamin B12 Hypersensitivity: A Retrospective Multicenter Study Justin Laube, MD Medical Reviewer Justin Laube, MD, is a dual board-certified integrative and internal medicine physician, retreat leader, and healing educator with over 15 years of experience caring for patients w

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That said, signs or symptoms that you may be low in vitamin B12 include: fatigue pale skin headaches symptoms of depression stomach issues difficulty focusing or concentrating pain or inflammation in the mouth or on the tongue burning or pins and needles feeling in your hands or feet muscle cramps vision changes Learn more: Signs and symptoms of B12 deficiency

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10.1038/s41598-018-26956-7 87 LiuM.LiL.ChuJ.ZhuB.ZhangQ.YinX.et al (2015)