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l carnitine ejection fraction l-Carnitine and heart disease NKF KDOQI Guidelines

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26 CostaC.StruysE.BootsmaA.Ten BrinkH.DorlandL.De AlmeidaI

l carnitine ejection fraction l-Carnitine and heart disease NKF KDOQI Guidelines

Previous metabolomic studies have highlighted disruptions in the TCA cycle, amino acid metabolism, and lipid metabolism during drug exposure, withdrawal, and re-exposure using rodent urine and serum following intraperitoneal (i.p.) injection of morphine 5 and heroin 5,6

l carnitine ejection fraction l-Carnitine and heart disease NKF KDOQI Guidelines

Bonavita E, Bertuzzi D, Bonavita J, and et al

l carnitine ejection fraction l-Carnitine and heart disease NKF KDOQI Guidelines

Wild-type IDH1 overexpression fully rescued the phenotype, demonstrating that the observations are not due to off-target effects (Extended Data Fig

l carnitine ejection fraction l-Carnitine and heart disease NKF KDOQI Guidelines

L-carnitine exerts hepatoprotective effects primarily through mitochondrial mechanisms

l carnitine ejection fraction l-Carnitine and heart disease NKF KDOQI Guidelines

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